About me
My name is Heng Li, an associate professor of Biomedical Informatics at Harvard Medical School and the Dana-Farber Cancer Institute. I study advanced computational methods and mathematical models to help researchers to understand biology better. I have worked on genomics, population genetics, phylogenetics and network dynamics. I led the design of the SAM format, created SAMtools/htslib and developed BWA and minimap2 among others. I also routinely collaborate with other biologists and computer scientists, and have been involved in multiple international projects such as the 1000 Genomes Project and the Human Pangenome Reference project.
I graduated from Nanjing University in China with a B.Sc. in physics. Under the supervision of Wei-Mou Zheng, I obtained my Ph.D. in theoretical biophysics in 2006 from the Institute of Theoretical Physics, Chinese Academy of Science, while working at BGI in the same period. I was a postdoc of Richard Durbin before I became a research scientist at the Broad Institute in 2009.
At the time I am writing this page, my wife, my daughter and I are living
around Boston, United States. Our motherland is China, forever.
Selected Publications
- Cheng H., Concepcion G.T., Feng X., Zhang H., Li H. (2021) Haplotype-resolved de novo assembly with phased assembly graphs with hifiasm. Nat Methods, 18:170-175. [PMID: 33526886].
- Li H. (2018) Minimap2: pairwise alignment for nucleotide sequences Bioinformatics, 34:3094-3100. [PMID: 29750242]
- Li H., Durbin R. (2011) Inference of human population history from whole genome sequences, Nature, 475:493-436. [PMID: 21753753].
- Li H., Handsaker B., Wysoker A., Fennell T., Ruan J., et al. (2009) The Sequence alignment/map (SAM) format and SAMtools, Bioinformatics, 25:2078-2079. [PMID: 19505943]
- Li H. and Durbin R. (2009) Fast and accurate short read alignment with Burrows-Wheeler Transform, Bioinformatics, 25:1754-1760. [PMID: 19451168]